Intraneuronal Aβ: Was It APP All Along?
(Seubert et al., 1992; Haass et al., 1992). All the same, a parallel line of inquiry challenging the
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Grasping the Shadow Force: Immune Cells in ALS
related news story on Lincecum et al., 2010). Compounds that block the interaction between CD40 and its
Beta-Catenin and PS1
caspase mediated cleavage of PS1 (at a.a. 329 and 341) during apoptosis (Tesco, et al., 1998). FAD
Cerebrometabolic Deficiency in Alzheimer's Disease
cholinergic mechanisms (Ragozzini et al., 1998). Gabrielle Strobel: That is interesting. I look forward to
Herpes Simplex and Alzheimer’s—Time to Think Again?
in the brains of wild-type mice infected with Chlamydia pneumoniae (Little et al., 2004). More
Role and Control of Metal-Mediated Fibril Toxicity
protection against the Aβ toxicity (see Lovell et al., 1998). All told, the evidence points to iron- or
The AD8—Dementia Screen Ready for Prime Time?
questionnaire to probe cognitive function, and was whittled down to a final eight items (Galvin et al., 2005).
Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus
influence biology in people with Down’s (see Korbel et al., 2009), the presence of an extra copy of the gene
Are Glia Active Participants in Neurodegenerative Disease?
injury (see Bush et al., 1999). Gabrielle Strobel And I believe Tony Wyss-Coray has data on active
Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look
tau-positive. Was the reverse true? I ask because if you look at our AD study (Busser et al., 1998), we found
Protein Folding and Neurodegeneration: Biophysics to the Rescue?
oligomerize and polymerize out of lipid environment, to self- and cross-associate (Koudinov et al., 1998
The Neuroplasticity Theory of Alzheimer's Disease
neurofibrillary tangles. The neurofilaments appear to clog dendrite segments (Ashford et al., 1998), which leads
Slow Aβ; Clearance Is ApoE4’s Modus Operandi in Late-Onset AD
Aβ production that might be regulated by synaptic activity (Kamenetz et al., 2003; Bero et al., 2011)
Neuroinflammation—A Prelude to Alzheimer's?
story and Breitner et al., 2011). Some researchers in the field have not given up hope that reining in
BDNF and Alzheimer's Disease—What's the Connection?
levels of synaptic vesicle proteins (Martinez et al., 1998; Pozzo-Miller et al., 1999), demonstrating
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